Z01 BC 010703 (Z01) | |||
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Title | Matriptase Inhibitory Agents as Anti-metastatics | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Roller, Peter | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $19,520 | Project Dates | 10/01/2006 - 04/30/2007 |
Fiscal Year | 2007 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Chemoprevention (30.0%) Chemotherapy (60.0%) Metastasis (50.0%) |
Breast (100.0%) Cervical Cancer (30.0%) Lung (30.0%) Non Hodgkins Lymphoma (25.0%) Prostate (30.0%) Thyroid (30.0%) Urinary System (30.0%) |
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Research Type | |||
Cancer Progression and Metastasis Chemoprevention |
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Abstract | |||
We discovered a highly potent bicyclic cage-like conformationally restricted, and proteolytically stable cyclopeptide, termed sunflower derived trypsin inhibitor, SFTI-1. We designed and synthesized a number of SFTI-1 analogs to improve its inhibitory specificity and serum stability. Some of the conformationally constrained cage-like bicyclic peptides and peptidomimetics demonstrate much better selectivity (more than 20-fold improvement) and stability. Our current goals are to develop more selective inhibitory analogs to SFTI-1, and to evaluate them in in vivo systems. |